Sveriges 100 mest populära podcasts

This Podcast Will Kill You

This Podcast Will Kill You

This podcast might not actually kill you, but Erin Welsh and Erin Allmann Updyke cover so many things that can. In each episode, they tackle a different topic, teaching listeners about the biology, history, and epidemiology of a different disease or medical mystery. They do the scientific research, so you don?t have to.   Since 2017, Erin and Erin have explored chronic and infectious diseases, medications, poisons, viruses, bacteria and scientific discoveries. They?ve researched public health subjects including plague, Zika, COVID-19, lupus, asbestos, endometriosis and more. Each episode is accompanied by a creative quarantini cocktail recipe and a non-alcoholic placeborita. Erin Welsh, Ph.D. is a co-host of the This Podcast Will Kill You. She is a disease ecologist and epidemiologist and works full-time as a science communicator through her work on the podcast. Erin Allmann Updyke, MD, Ph.D. is a co-host of This Podcast Will Kill You. She?s an epidemiologist and disease ecologist currently in the final stretch of her family medicine residency program. This Podcast Will Kill You is part of the Exactly Right podcast network that provides a platform for bold, creative voices to bring to life provocative, entertaining and relatable stories for audiences everywhere. The Exactly Right roster of podcasts covers a variety of topics including science, true crime, comedic interviews, news, pop culture and more. Podcasts on the network include My Favorite Murder with Karen Kilgariff and Georgia Hardstark, Buried Bones, That's Messed Up: An SVU Podcast and more.

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Ep 135 Menopause is whatever you want it to be

For our season 6 finale, we?re spending some time with menopause. How many nicknames can you think of for menstruation? Quite a few, I?m sure. ?That time of the month?, ?Aunt Flo?, ?the red wave?, ?period?, the list goes on. But what about euphemisms for menopause? We?ve got ?the change? or ?change of life?, ?climacteric?, and? that?s it? There may be more out there, but the comparison is revealing. Despite the fact that roughly half of the global population has or will one day experience menopause, the lack of nicknames demonstrates the silence, often tinged with shame, still enveloping it. In this episode, we explore the roots of this silence and the many historical misconceptions about menopause that frame our current perspective. We also examine the effect that this silence has on our understanding of the physiological processes underlying this transition. Why do some people experience symptoms and others do not? Why do humans experience menopause? What is the grandmother effect? What?s the latest on hormone replacement therapy? These are only a sampling of the many questions we delve into in this info-packed, frustration-laden, and eye-opening episode. Learn more about your ad choices. Visit megaphone.fm/adchoices
2024-02-13
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Ep 134 Tonsils: Underestimated and underappreciated

Raise your hand if you or someone you know has had their tonsils removed. If your hand is sky-high, there?s a pretty good chance that you (or that person you know) are from the US and were born before 1980. Of course, maybe that?s not the case, but tonsillectomies certainly fit in the category of 20th-century fads, along with Tamagotchis and the Atkins diet. While the procedure is still widely performed today (and for very good reasons), the frequency of tonsillectomies has dropped drastically from mid-20th century rates. In this episode, we explore why tonsillectomies became so popular, when they fell out of favor, and what about tonsils makes them worthy of removal. Tune in to be horrified by ancient tonsil removal techniques, shocked at how long it takes new knowledge to change policies, and appreciative of just how cool tonsils actually are. Learn more about your ad choices. Visit megaphone.fm/adchoices
2024-01-30
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Ep 133 Parvoviruses: Who let the dogs (and their viruses) out?

This one?s not just for the dogs. It?s also for the cats, the raccoons, the wax moths, the birds, the mice, and so many other critters. Oh, and of course the humans. Even though most of us may be familiar with parvovirus through our canine friends, the world of parvoviruses is much larger. In this episode, we explore that world, focusing first on the biology of these tiny DNA viruses and how they make us sick before tracing the history of their discovery and the pandemic spread of canine parvovirus just a few short decades ago. We are joined by the amazing Dr. Steph Horgan Smith who acts as our veterinary tour guide through the animal world of these viruses and why vaccination against them is so incredibly important. Finally, we round out the episode with some of the latest research on these viruses, featuring some very cool, very promising work on using the dependoparvoviruses as a tool for gene therapy. Tune in to learn where Fifth disease got its name, what role raccoons may have played in the emergence of canine parvovirus, and so much more. Learn more about your ad choices. Visit megaphone.fm/adchoices
2024-01-16
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Ep 132 Osteogenesis Imperfecta: All bones about it

Often, the more we learn about a disease, the more we learn about ourselves and the world around us. The story of the genetic disorder osteogenesis imperfecta (OI), colloquially known as brittle bone disease, illustrates this perfectly. As researchers continue to uncover the mechanisms responsible for OI development and progression, the better we understand the varied and crucial roles collagen plays in all parts of our biology. As historians attempt to trace how that knowledge has accumulated over time, the more we can clearly see how science rarely progresses consistently but rather erratically and is prone to interruption. And as we assess where we are with OI treatment and research today, the more apparent the gap is between knowledge and application, and just how critical lived experiences are in understanding a disease. In this episode, we explore these aspects of osteogenesis imperfecta, and we are thrilled to be joined by Natalie Lloyd, who shares her experience with OI as our firsthand account. Natalie is a New York Times bestselling author of novels for young readers, whose recently published award-winning book Hummingbird tells the story of a young girl with OI. Heartwarming, magical, and brilliant, this wonderful book is a must-read. Tune in today! Learn more about your ad choices. Visit megaphone.fm/adchoices
2024-01-02
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Ep 131 Parkinson?s Disease: Dopamine & discoveries

Parkinson?s is a disease of many dimensions. On the shelves of any bookstore or library you?ll find at least a handful of titles exploring the topic from a myriad of perspectives, and extending that search to the internet will turn up dozens upon dozens more options: how-to guides for the recently diagnosed, in-depth textbooks exploring the neurophysiology of disease development, memoirs about caregiving for people with Parkinson?s, books offering a tour through the history of research advancements. The choices seem limitless and maybe a tad overwhelming. But that?s where we come in. In this episode, we take you through many of the dimensions of Parkinson?s disease, from its complicated biology, still shrouded in mystery, to its history, peppered with transformative moments like the introduction of dopamine. We round out the episode by exploring the tremendous amount of promising research on the horizon, leaving us feeling like we?re *this* close to yet another revolution in Parkinson?s disease treatment. If you?ve ever wondered what dopamine does, who Parkinson was, and what might be next for this disease, this episode is for you. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-12-12
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Ep 130 Cocoliztli: We do love a salty dish

In the 16th century, a series of deadly epidemics swept through much of the region of Mesoamerica known as the Aztec Empire, killing untold millions. By the start of the first of these epidemics, the area had become woefully accustomed to devasting epidemic disease, as the Spanish conquistadors had introduced smallpox, measles, typhus, and influenza, among other infections. But this disease, with its tendency to induce massive hemorrhage, fever, jaundice, and rapid death, seemed different from those now familiar infections, and so was given a new name: cocoliztli. People watched in horror as cocoliztli overtook town after town, village after village, sometimes killing as much as 80% of the population and leaving nothing but desolation in its wake. Hundreds of years after the epidemics ended, debate about the pathogen responsible for cocoliztli remains. In this episode, we?re going deep down the rabbit hole of this medical mystery, linking the spread and nature of these epidemics with the characteristics of the many pathogens that have been proposed over the years. We draw from contemporary accounts, ecological analyses, and even a recent ancient DNA study to make our evaluations, but do we ever get to the bottom of cocoliztli? Tune in to find out. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-11-28
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Ep 129 Lymphatic Filariasis: Hiding in plain sight

With a history extending back millennia, with a biology that leads to permanent disability for tens of millions of people globally, and with a bacterial endosymbiont that may prove to be its Achilles heel, the filarial parasites that cause lymphatic filariasis are quite the complex creatures. In this episode, we explore the intricacies of this neglected tropical disease - also known as elephantiasis. We start by examining its complicated ecology involving many mosquito and parasite species, before moving on to its tricky biology where we finally answer the age-old question, ?What is the lymphatic system anyway??. Next, we move on to the convoluted history of lymphatic filariasis, where it holds the distinction of being the first disease recognized as mosquito-borne. We wrap up the episode with a look at its present global status, grappling with some current figures on the tremendous global burden of this disease and investigating some exciting treatment developments that will hopefully bring relief to the hundreds of millions of people at risk of developing this debilitating disease. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-11-14
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Ep 128 Skin Cancer: We love and fear the sun

For every article about the risks of sun exposure or a guide to sunscreens, you don?t have to look far to find one about the health benefits of sunshine or a how-to for achieving the best tan. Messaging around sun exposure is mixed, to say the least, and it?s no wonder that despite having more sun protection tools than ever before, rates of skin cancer have never been higher. In this episode, we delve into the relationship between UV radiation and skin cancers, answering your (sun)burning questions about the different types of cancers and how sunscreens actually work. We then explore the history of sun protective methods and how attitudes around tanning have changed dramatically over time. We wrap up the episode with a look at rates of skin cancers around the globe today and exciting research showing the benefits of sunscreens as well as how AI might be used to help diagnose skin cancer. Tune in for an info-packed episode that will have you reaching for that sunscreen bottle. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-10-31
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Ep 127 Bhopal: The 1984 Union Carbide Disaster

On the night of December 2, 1984, a deadly gas leak at the Union Carbide pesticide plant in Bhopal, India led to what has been described as the world?s worst industrial disaster. In the immediate aftermath of the gas leak, thousands of people died and hundreds of thousands were injured from exposure to the toxic gas methyl isocyanate. But long after the international headlines and news reports dwindled to silence, long after Union Carbide paid a paltry settlement to survivors, long after the disaster faded from much of the world?s memory, the gas leak continues to haunt the residents of Bhopal. In this episode, we trace the path of methyl isocyanate from initial discovery to the night of the disaster and the years that followed. We then explore what about this gas makes it so very deadly before assessing how the contamination still present at the site is causing health problems for residents decades after the gas leak. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-10-17
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Ep 126 Migraine: A Cacophony in Four Movements

?Throbbing, pulsating pain.? ?Like a drill boring into your head.? ?As though your head is gripped by a vise.? ?Stabbing pain hammering through your brain.? There is no shortage of metaphors used to describe the horrific, incapacitating pain of migraines. But try as we might, can any of them truly convey what it feels like to be at the mercy of such pain? In many ways, migraines reveal our shortcomings: with language that fails to accurately describe pain, with empathy when we continue to dismiss migraines as ?just really bad headaches?, with medicine as we struggle to find reliable treatments and preventatives, and with biology as we fail to understand the complete pathology of this condition. In this episode, we do our best to explore these shortcomings by deep diving into what we do know about the biology and history of migraines. Why do some people get migraines and others don?t? How do certain medications work? What the heck is going on with aura? Have migraines always been around? How have people dealt with them or perceived them historically? What?s on the horizon for migraines in the future? As always, we?ve got lots of questions and lots of answers for you, so tune in today! Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-10-03
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Ep 125 Blastomycosis: How fungus became amongus

Fungal infections don?t often make an appearance on this podcast, but when they do, you know you?re in for a wild ride. In this episode, we explore the rare but potentially deadly fungal infection blastomycosis. We trace the journey of Blastomyces spores as they depart from their cozy homes of decomposing wood and make their way first into mammalian lungs before possibly moving into the skin, intestines, and brain. How and why these fungi can be so deadly is our next stop, one that takes us into an unexpected direction: the fall of dinosaurs, the rise of mammals and the role that pathogenic fungi played in this transition. We delve into why comparatively few fungi are pathogenic to humans and how our warm-bloodedness may protect us. But, as we discuss in the episode?s conclusion, that protection may be weakened as our warming planet selects for fungi that can tolerate increasing temperatures. Dinos, dogs, deep time, and deadly outbreaks - this episode has it all. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-09-19
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Ep 124 The full spectrum of color vision deficiency

There?s no denying that human imagination is a powerful thing. It has led us to create incredible works of art, literature that transports its readers to other realms, technology that revolutionizes the way we communicate and travel, music and film that makes us laugh, cry, and hit repeat. But our imagination often falls short when trying to conceive of the world from another person?s perspective, especially when it comes to senses. In this episode, we delve into one of the most prominent examples of this: color vision and color vision deficiencies. First, we take you through how color vision works and just how non-universal this experience is. We then explore the origins of color vision and what evolutionary significance it may have held before getting into the discovery of color vision deficiency and its impact on industry. We close out this colorful episode by chatting about some of the latest developments and products geared towards those with color vision deficiency. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-09-05
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Ep 123 Hand, Foot, and Mouth (and Butt?) Disease

Hand, foot, and mouth disease (HFMD). The dreaded scourge of daycares, kindergartens, even occasionally college campuses, and the topic of this week?s episode. From the multiple viruses that cause HFMD to the wide array of symptoms (bye bye, fingernails), from the relatively recent discovery of this disease to the ancient origins of all viruses (deep time, y?all), from the changing nature of outbreaks to the development of potential vaccines (fingers crossed) - in this episode we?re going way beyond the basics of hand, foot, and mouth disease. Whether or not you?ve had the pleasure of being up close and personal with this disease, this episode is sure to leave you slightly horrified/mildly impressed by the infectiousness, longevity, resilience, and deep roots of the HFMD viruses. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-08-22
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Ep 122 Asthma: A phlegmy episode

Most of us are familiar with asthma. Maybe you have the disease yourself or maybe a friend, family member, or coworker has it. Or maybe you?ve just watched a tv show or movie featuring a character with asthma. However you learned about this disease, you probably still have some lingering questions about it, like ?how do inhalers work??, ?what are the different types of asthma??, ?where does the word asthma come from??, ?can other animals get asthma??, and ?can Erin and Erin tell me everything they possibly can about asthma?? The answer to that last question is a resounding yes, and the answers to the others you?ll find in today?s episode, where we take you through the complicated but somehow also straightforward biology of this disease, the long history of asthma peppered with firsthand accounts, and the promising research that may transform the way we live with this disease. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-08-08
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Special Episode: Ed Yong & An Immense World

Our final TPWKY book club selection of the season will test the limits of your imagination by asking you to consider what it might be like to smell the world through the nose of a dog or to see flowers through the ultraviolet vision of a bee. It will make you ponder the tradeoffs inherent in sensory perception and what an animal?s dominant senses can tell us about what is most important to their species. It will have you contemplating what the future holds for sensory research, both in terms of what new senses we might discover as well as the impacts of sensory pollution on an ecosystem. In short, it will change the way you perceive the world. Pulitzer Prize-winning science journalist Ed Yong joins us to chat about his incredible book, An Immense World: How Animal Senses Reveal the Hidden Realms Around Us. Yong, whose other book I Contain Multitudes is another TPWKY favorite, leads us on an expedition beyond the boundaries of human senses as we chat about what an octopus tastes, how the line between communication and perception is blurred in electric fish, the evolutionary arms race between bats and moths, and even the long-standing question of why zebras have stripes. Tune in for the riveting and magical conclusion to this season?s miniseries. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-08-01
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Ep 121 Tularemia: Hare today, gone tomorrow

The CDC?s list of highest priority bioterrorism agents is a short one, with only six pathogens making the cut. Among the more familiar names on the list, such as anthrax, botulism, plague, smallpox, and viral hemorrhagic fevers, is the topic of today?s episode: Francisella tularensis. Unless you?re a hunter or work with small mammals, you may not recognize the name of this pathogen or the disease it causes - tularemia - let alone the characteristics that earned it a place on the CDC?s list. By the end of this episode, though, all that will have changed. Join us as we explore why this pathogen?s brutal biology makes it a force to be reckoned with, how the history of its discovery has surprising origins in the devastating 1906 San Francisco earthquake, and what promises future research may hold for protection against this deadly disease. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-07-25
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Special Episode: Deborah Blum & The Poison Squad

Oh, to taste the food of the past. Strawberry jam made from farm-fresh strawberries. Milk straight from the cow. Cookies baked with freshly churned butter and brown sugar. Because that?s how it was, right? Everything used to be fresher, more pure, unadulterated by preservatives or additives, right? Our latest TPWKY book club pick shows us just how wrong that notion is. Science journalist and Pulitzer Prize-winning author Deborah Blum joins us this week to chat about her book, The Poison Squad, which tells the story of the fight for food safety regulation in the United States at the turn of the 20th century. In our conversation, Blum rips off those rose-tinted nostalgia glasses and reveals that strawberry jam rarely contained strawberries, milk could include a mix of formaldehyde and pond water, butter had borax, and brown sugar was mostly ground up insects. Until one man, chemist Harvey Wiley, stepped up and spearheaded the campaign for food safety legislation, all of these horrific practices of food adulteration were entirely legal. Tune in to learn what Wiley was up against and some of the tactics used in his struggle, including the wild story of the experiment that gave this book its title. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-07-18
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Ep 120 Acetaminophen/Paracetamol: Pain. Killer.

It?s safe to assume that the vast majority of you have a bottle or blister pack of acetaminophen/paracetamol/Tylenol/Panadol in your home medicine cabinet, and an even vaster majority of you have taken the medicine at some point in your life. After all, acetaminophen/paracetamol is one of the most, if not the most, widely used medications worldwide. Despite its near ubiquity, many unanswered questions remain. How does it actually work? Should safe dosage guidelines be revisited? Why on earth does it have multiple names? And finally, who was responsible for the Tylenol murders in 1982? In this jam-packed episode, we do our best to make sense of the mysteries surrounding this drug, weaving our way from the pharmaceutical nitty gritty of acetaminophen/paracetamol to the bizarre story of its discovery, from the horrific crimes that shocked a nation and revolutionized consumer safety standards to the ongoing discussions of whether we?re under- or overestimating how safe this medication actually is. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-07-11
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Special Episode: Dr. Andrew Wehrman & The Contagion of Liberty

Riots over inoculations. Large-scale quarantines and lockdowns. Criticisms of government action (or inaction) during disease outbreaks. The spread of mis- and disinformation about the safety of immunizations. You may be thinking, ?this is a COVID episode, isn?t it??. Not quite. In this latest installment of the TPWKY book club we?ll be discussing another key period in US history that had profound, long-lasting impacts on public health and access to medical care: the American Revolutionary War, when liberty from smallpox was even more important to the American colonists than independence from Great Britain. Our time travel tour guide is Dr. Andrew Wehrman, Associate Professor of History at Central Michigan University, who joins us to discuss his fascinating book The Contagion of Liberty: The Politics of Smallpox in the American Revolution, published in December 2022. As our conversation reveals, public demand for inoculation was so great that riots were held to protest unequal access, our current lack of universal healthcare systems has incredibly deep roots, and George Washington?s greatest legacy may in fact be his ability to change his mind when presented with new information. With the Fourth of July just one week ago, what better time to consider this fresh perspective on the American fight for independence and freedom from disease. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-07-04
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Ep 119 Marburg virus: Too fast, too furious

In early February and late March of this year, separate outbreaks of Marburg virus were declared in Equatorial Guinea and in the United Republic of Tanzania. For several months, news of these outbreaks and other sporadic cases made headlines globally, as public health officials watched the number of cases and suspected cases climb, calling to mind previous outbreaks of Marburg virus's relative, the deadly Ebola virus. Fortunately, the WHO declared both outbreaks over in early June, but the threat of this hemorrhagic virus remains. In this episode (recorded in April 2023) we explore why the biology Marburg virus makes it such a deadly pathogen, what its evolutionary history and the history of its discovery can tell us about the changing landscape of pathogen spillover, and how the recent outbreaks reveal how much we still don't know about this virus. Tune in for everything you ever wanted to know about Marburg virus and more. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-06-27
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Special Episode: Dr. Steven Thrasher & The Viral Underclass

Are viruses the ?great equalizers? that some people claim them to be? Are we all similarly susceptible not only to infection from viruses but also to the consequences from infection? The short answer is no. The longer answer can be found in this week?s book club pick, The Viral Underclass: The Human Toll When Inequality and Disease Collide by Dr. Steven Thrasher. Dr. Thrasher, the inaugural Daniel H. Renberg Chair and Assistant Professor of Journalism at Northwestern University, joins us to discuss how racism, classism, sexism, ableism, stigma, and other forms of oppression intersect to create a viral underclass, a group of individuals that are disproportionately susceptible to and impacted by viruses. Our conversation takes us through several of these vectors of the viral underclass as well as personal stories that illustrate how social and political structures punish certain communities for getting sick while others profit. Part memoir, part academic discussion, part journalism, and entirely groundbreaking, The Viral Underclass is an incredibly timely book that demonstrates the ways that viruses amplify and exacerbate existing inequalities while also underlining how we are truly all in this together. Our interconnectedness means that if one of us is vulnerable to infection, then we all are. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-06-13
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Ep 118 Asbestos: Corruption and cancer and corporate greed, oh my!

An entire generation probably first learned the word ?mesothelioma? and its link to asbestos from those ubiquitous commercials in the 1990s and 2000s. You know the one: ?if you or a loved one has been diagnosed with mesothelioma you may be entitled to financial compensation.? These commercials made it seem like mesothelioma suddenly came out of nowhere. Was this a newly discovered disease? Wasn?t asbestos banned? How did asbestos cause mesothelioma? Heck, what even was asbestos? By seeking to answer all those questions and more, this episode picks up where those commercials left off. We detail how teeny tiny asbestos fibers can wreak immense devastation, untangle the long human history of asbestos products, and assess the current status of this fibrous mineral, which is disappointingly far from banned worldwide. No story of asbestos would be complete without a spotlight on the town of Libby, Montana, where brave crusaders continue to fight against a company whose callous negligence led to injury, death, and widespread environmental contamination. Tune in to find out where salamanders, The Wizard of Oz, Charlemagne, and The River Wild fit into the story of asbestos. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-05-30
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Special Episode: Mary Roach & Fuzz

Where can you find banana-stealing macaques, dumpster-diving bears, flower-destroying gulls, and dangerously-exploding trees all in the same place? In a book by Mary Roach, of course. In this TPWKY book club episode, we?re joined by world?s funniest science writer and award-winning author to chat about her latest book Fuzz: When Nature Breaks the Law, a rollicking tour of the many ways that humans and wildlife clash and the varied attempts to mitigate this conflict. Our conversation carries us across the globe as we discuss why ?man-eating cat? is a misnomer and how the Vatican takes pest control very seriously, and through time as we contemplate the changing nature of conservation and the hopeful future of human-wildlife conflict. If you?ve ever wondered about the forensics of wildlife attacks (in other words, what?s going on in the Ponderosa Room?) or whether scarecrows work like they?re supposed to (spoilers, they don?t), then this is the episode for you. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-05-16
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Ep 117 Bedbugs: Bug-bitten and bedeviled

This just might be our itchiest episode yet, and for that we sincerely apologize. But it might also be one of our most fascinating and fun episodes yet, and for that we are proud. Whether or not you have personal experience with bedbugs, the mere mention of these vampiric critters is often enough to inspire skin-crawling horror in us all. But in this episode, we also make a case for their appreciation. How can you not admire (from a distance, of course), their incredible ability to go for months or even a year without feeding? Or that their saliva contains all kinds of proteins that slow blood clotting or dilate our blood vessels? Or that the ubiquity of these bugs during the Industrial Revolution drove massive changes in furniture design? From the biology of a bedbug bite to the impressively long history of these blood-feeding arthropods, we present the story of bedbugs in more detail than you ever knew you wanted (and trust us, you do). Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-05-02
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Special Episode: Dr. Kate Clancy & Period

Menstruation. Is there any other biological process that is so widely experienced yet is still discussed in hushed tones or with an air of disgust? Period product commercials that never mention menstruation (and what?s with the blue liquid?), sex education classes covering what periods are without advising how to manage them, the endless list of menstruation euphemisms, prominent evolutionary hypotheses dismissing periods as maladaptive, even proposed laws forbidding the discussion of periods in school (looking at you, Florida) - these are just a few examples of the ways that we have been taught to be ashamed or grossed out by a natural biological process. In this TPWKY book club episode, we chat with Dr. Kate Clancy, Professor of Anthropology at the University of Illinois, about her recently published book Period: The Real Story of Menstruation, a compelling must-read that examines both scientific and societal perceptions of periods. Our conversation with Dr. Clancy takes us through the origins of period stigma, the leading hypotheses as to why we get periods, the observed link between the SARS-CoV-2 vaccine and menstruation, the hopeful period future, and so much more. Tune in to learn where a uterus pancake fits into this discussion and stay to have all of your period myths busted. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-04-18
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Ep 116 It's never lupus (except this time)

Even if you haven?t watched the TV show House MD, you?re probably familiar with the phrase ?it?s never lupus?. But have you stopped to consider why it?s never lupus? Or why lupus is so often suspected in the first case? Well, dear listeners, this episode aims to get at the heart of those questions, which is easier said than done. Like many other autoimmune diseases, lupus erythematosus continues to baffle, but we know a lot more now than we used to. In this episode, we take you through that knowledge as best we can and then trace the steps of how we came to first recognize, then describe, and then treat lupus, a journey that takes us through how we learned about autoimmunity in the first place. If you?ve ever been curious about how lupus got its name (wolf bite, anyone?) or what the pregnancy compensation hypothesis could mean for this and other autoimmune diseases, then this is the episode for you. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-04-04
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Ep 115 Altitude Sickness: Balloons though?

In our episode on the bends, you joined us as we explored how low we can go. Now we?re back with a similar invitation: come along to learn how high we can fly (and what happens to our bodies when we get up there). In this very special episode, we examine the short-term effects and potentially deadly consequences of life at great heights and ask how we came to understand the relationship between altitude, oxygen, and health. This journey begins earlier than you may have guessed, back to a time before oxygen was discovered, and winds through unexpected avenues, including misadventures in hot air balloons and early experiments demonstrating the vitality of air, as we trace how the pieces of high altitude physiology were put together. A big part of what makes this episode so very special is our guest, Dr. Jonathan Velotta, Assistant Professor of Evolutionary Biology at the University of Denver, who joins us to chat about some of the incredible ways that humans and other animals have adapted to live at high altitude. Tune in for a bird?s-eye view of what it?s like to have a high life. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-03-21
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Special Episode: Angela Saini & Superior

Listeners of this podcast are likely no strangers to the horrifying history of eugenics, a topic that has made an appearance in our episodes on epilepsy, Huntington?s disease, hemophilia, sickle cell anemia, and many others. We have touched on eugenic policies that prohibited marriage, encouraged and permitted forced sterilization, and restricted immigration in the U.S. in the early 20th century. But what we haven?t explored in great depth are the origins of eugenics as well as its disturbing persistence in scientific research today. This week?s TPWKY book club selection, Superior: The Return of Race Science, goes way beyond filling in those gaps, offering a brilliant, disturbing, and much-needed examination of the history and continued practice of race science. In this bonus episode, Angela Saini, award-winning journalist and author of Superior (and many other must-read books), joins us to discuss this history, exploring questions such as ?what role did colonialism play in the creation of racial categories??, ?where does the public image makeover of Neanderthals fit into this story??, ?what does race science look like today??, and ?how did race science make an appearance during the COVID pandemic??. Tune in for a fascinating interview that highlights the need to remain vigilant against the insidious and damaging practice of race science. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-03-14
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Ep 114 Listeria: It put dairy on the map

For many of us, our encounters with listeria may not go beyond reading the occasional headline about an outbreak from contaminated hot dogs or listening to our doctor advise us to avoid certain foods while pregnant. But as we explore in this episode, the story of Listeria monocytogenes is more complex, scary, and unexpected than you may have imagined. Join us this episode as we trace the dual-natured and sometimes extremely deadly infections this pathogen can cause, examine how the industrial revolution and cattle movements may have altered the landscape of Listeria monocytogenes, and ask why cell biologists are so enamored with this bacterium. One thing?s for sure: this isn?t your typical food-borne pathogen. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-03-07
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Special Episode: Sarah Everts & The Joy of Sweat

You may be wondering if there?s a typo in this week?s TPWKY book club selection - The Joy of Sweat? Are we supposed to find joy in this secretion? Shouldn?t it be The Inconvenience of Sweat? Some of you sauna-goers or hot yoga enthusiasts may already welcome sweat (at the right time and place, of course), but I?m guessing there are plenty of you out there that do everything you can to prevent perspiration and the odor that frequently accompanies it. In this bonus episode, Sarah Everts (@saraeverts), author of The Joy of Sweat: The Strange Science of Perspiration and Science Journalism Chair at Carleton University?s School of Journalism, joins us to discuss why we should reconsider our stance on sweat and instead recognize it for the superpower it is. Or at the very least, be grateful that we don?t do what vultures do to cool off. Our conversation covers topics as far-ranging as sweat forensics, the evolutionary significance of body odor, the shameful marketing of early antiperspirants, the wild world of sweat dating, and so much more. Whatever your current feelings towards perspiration, this episode will have you thinking more about sweaty secretions than you ever have before (and enjoying every second of it). Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-02-28
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Ep 113 Vitamin D: The D stands for drama

There is no shortage of ailments that vitamin D has been claimed to prevent or cure - various types of cancers, heart disease, COVID-19, diabetes, an assortment of autoimmune conditions, just to name a few. What is it about this micronutrient that leads people to behold it as a panacea? In this episode, we sift through what we know about the biology of vitamin D, along with what happens when you don?t have enough of it, in an attempt to discern what might be overhype and what might be underhype when it comes to vitamin D and health claims. And there certainly is ample reason for excitement over this micronutrient, as its deep, deep evolutionary history reveals just how many biological processes in which vitamin D is intimately and vitally involved. The consequences of vitamin D deficiency form a large part of its human history, as soaring rates of rickets during the Industrial Revolution drew the interest of researchers intent on pinpointing the cause of this disease. As is typical for this podcast, the more we know, the more questions we have, like ?who decided what counts as deficiency??, ?how much vitamin D should people be getting??, and ?what is vitamin D really telling us??. Tune in for plenty of sunshine, cod liver oil, and drama over vitamin D. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-02-21
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Special Episode: David Quammen & Breathless

What do you get when you combine a love of reading with an interest in biology/public health/medical history and a background in podcasting? The TPWKY book club, of course! This season?s miniseries of bonus episodes features interviews with authors of popular science books, covering topics ranging from why sweat matters to the history of food safety, from the menstrual cycle to the persistence of race science and so much more. So dust off that library card, crack open that e-reader, fire up those earbuds, do whatever it takes to get yourself ready for the nerdiest book club yet. We?re starting off this book club strong with a discussion of Breathless: The Scientific Race to Defeat a Deadly Virus, the latest book by award-winning science writer David Quammen (@DavidQuammen). Breathless recounts the fascinating - and sometimes frightening - story of how scientists sought to uncover the secrets of SARS-CoV-2, the virus that causes COVID. In this interview, Quammen, whose 2012 book Spillover explores the increasing pathogen exchange occurring among humans, wildlife, and domestic animals, shares with us how he decided to write Breathless and why this story of discovery needs to be told. Our conversation takes us into musings over why we saw this pandemic coming yet could not keep it from happening, the controversy over the origins of SARS-CoV-2, and the question of whether future pandemics are preventable or inevitable. Through this discussion, we find that the global response to future pandemics depends just as much on locating the gaps in our knowledge about this virus as it does on applying what we have learned so far. Tune in for all this and more. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-02-14
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Ep 112 Epilepsy: It?s always the phlegm

Only our second episode of the season and we?re already getting in over (and inside) our heads with one of the biggest topics we?ve taken on yet: epilepsy. In this episode, we navigate the constantly changing definitions of epilepsy, make our way through the many different types of seizures, and dig into the inner workings of the brain as we attempt to understand the pathophysiology of this disease. And that?s just the biology section! The history of epilepsy proves to be just as intense, as shown by the multitude of meanings this disease has held over thousands of years. The past merges with the present - and maybe the future - when we delve into some of the technologies that have helped us to gain a clearer picture of this disease and may lead to improvements in prevention, detection, and management of seizures in years to come. Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-02-07
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Ep 111 RSV: What?s syncytial anyway?

We?re kicking off our sixth season in the same way we ended our fifth: with another headline-making respiratory virus. But as our listeners know, not all respiratory viruses are the same, and it?s often those differences among them that play the biggest role in their spread or the symptoms they cause. This episode, we?re exploring the virus that everyone has been talking about lately. No, not that one. Or that one. The other one. Yes, we?re talking about respiratory syncytial virus, or RSV. For many people, the recent surge in RSV infections that dominated headlines this winter may have been the first time they had heard of this viral infection or realized how deadly it could be. But for others, RSV has long inspired fear and dread. In this episode, we Erins explain why this virus deserves such notoriety, how long we?ve recognized the dangers of infection, and what hope the future may hold for novel RSV treatments or vaccines. If at any point you?ve wondered what all the fuss is about this virus or how to pronounce syncytial, then this is the episode for you! Learn more about your ad choices. Visit megaphone.fm/adchoices
2023-01-24
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Ep 110 Influenza, Take 2: Fowl Play

Ep 110 Influenza, Take 2: Sitting Ducks; Fowl Play Over five years ago, on October 31, 2017, the very first episode of This Podcast Will Kill You premiered, an action-packed (and mildly disorganized) tour of the influenza virus and the 1918 flu pandemic. So much has happened since that episode?s release, both within the podcast and in the world of public health, not the least of which is a respiratory virus pandemic. Given this distance from the podcast?s beginning and the added perspective of experiencing a pandemic firsthand, we decided to circle back to where we started by revisiting influenza for our fifth season finale. In this episode, we provide a bird?s eye view of influenza viruses overall, from how they make you sick to the long history of influenza pandemics and where we stand with case numbers in recent years. Then we dig deeper by giving you a different kind of bird?s eye view: a close examination of highly pathogenic avian influenza, especially H5N1. How is this virus different from your standard seasonal influenza strain, where did it come from, and how worried do we need to be? Are we just a bunch of sitting ducks? Tune in to find out. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-11-22
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Ep 109 Chikungunya: Not dengue (or is it?)

Somehow it?s taken us until the penultimate episode to cover this season?s first mosquito-borne virus. But we assure you, this episode is well-worth the wait. Although Chikungunya virus is often lumped in with dengue or Zika, the unique characteristics that distinguish Chikungunya virus from these other arboviruses are just as important to note as the similarities among them. In this episode, we explore these differences and similarities in the biology of Chikungunya virus before reassessing what we thought we knew about the history of this disease, a history that is presently under revision. Finally, we wrap up the episode as we always do, by taking stock of where we stand with Chikungunya virus today. Tune in for a good deal of dengue compare/contrast, a whodunnit (or whichdiseaseisit) in the history of these two diseases, and a frustrating attempt to gather present-day case numbers. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-11-08
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Ep 108 Gout: Toetally fascinating

Although today we tend to think about diseases in terms of signs and symptoms, tests and treatments, that hasn?t always been the case. For much of history, diseases carried with them a deeper meaning beyond the pathophysiological processes leading to their development. A diagnosis was as much about the identity and personality of an individual as it was about the disease itself, and this was especially the case for the topic of today?s episode: gout. But before we get into the tangled history of this ?monarch among maladies?, we first break down its biology and possible evolutionary origins. Once we have a solid understanding of this crystalline illness, we turn our attention to the changing perceptions of gout over time and why gout was once a welcomed diagnosis, in sharp contrast with so many other diseases. Finally, we take stock of gout around the world today, no easy feat. Tune in for a fascinating deep dive into this incredibly common but often overlooked illness. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-10-25
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Ep 107 Sepsis: It's a mess

Over the years of the podcast, we have often struggled with questions of why: why pathogens act the way they do, why certain people get sick while others don?t, or why we know little about some diseases. This episode is no exception - sepsis certainly inspires many ?whys?. But for perhaps the first time on the pod, we find ourselves grappling not only with ?why?? but also with ?what??. What, indeed, is sepsis? Ask a dozen doctors and you may get a dozen different answers. Our first goal for this episode is to sift through the various definitions of sepsis and what we know about its pathology to get a firm handle on this deadly consequence of infection. We then turn our sights to a thrilling period of sepsis history - Joseph Lister and his carbolic acid spray - before attempting to address the status of sepsis around the world today. By the end of the episode, your picture of sepsis may not be crystal clear, but hopefully the edges are a little less blurry. And helping us to de-blur the edges of sepsis is the wonderful Katy Grainger, leading sepsis and amputee advocate and on the Board of Directors of Sepsis Alliance, who shares with us her harrowing sepsis experience. You can learn more about Katy?s story and advocacy work by following her on instagram (@katysepsisamputee), TikTok (@katysepsisamputee), Facebook, or by checking out www.sepsis.org. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-10-11
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Ep 106 Turner Syndrome: Let's talk about X

Are you in the mood to chat chromosomes, specifically the X chromosome? If so, have we got the perfect episode for you! You may have come across the definition of Turner syndrome as a genetic condition resulting from the partial or complete loss of an X chromosome, but what does that actually mean? What is the X chromosome, what does it do, and why is it so important? We attempt to answer these questions with our exploration into the biology of Turner syndrome before setting our sights on the who?s and when?s of the X chromosome and Turner syndrome. Our path through the history of these bundled packets of genetic material wouldn?t be complete without some fascinating detours, such as an exploration into the inspiring life of Nettie Stevens and the beautiful variations in sex chromosomes found in the animal kingdom. Finally, we wrap up our episode by taking stock of how much progress we?ve made with Turner syndrome treatment and research but also how far we still have to go. Tune in for all this and more! Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-09-27
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Ep 105 Down in the Mumps

We?ve covered measles, we?ve taken on rubella, and now we?re finishing up the classic MMR vaccine by exploring the other M: mumps. To some listeners, mumps may be a painful childhood memory while to others it?s just a letter in a vaccine they were too young to remember getting. But by the end of this episode, we promise that you?ll all be much more familiar with this strange little virus. How does the mumps virus make you sick and give you that classic swollen face look? What is so bad about the mumps that Maurice Hilleman decided to snag a sample from his sick daughter to make a vaccine? Where do we stand with mumps today and what do declining vaccination rates have to do with those not-so-great numbers? Tune in to hear our take on all these questions and many more in this classic TPWKY episode. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-09-13
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Ep 104 The Bends: Industrial Revolution, baby

Don your wetsuit, grab your oxygen tank, and securely fasten your mask, because this week we?re going on our deepest dive yet. In this episode, we?re plumbing the depths of decompression sickness, aka the bends, to get a better handle on how gases and pressure can be so very deadly. We start out with a bit of Gases 101, examining how decompression sickness occurs and why it affects your body in the ways it does. Next, we explore the not-so-distant history of this disease, a history that includes far more tales of bridge engineering than it does of SCUBA diving (but just as fascinating). Finally, we rise to the surface, but not too quickly, with a look at decompression sickness around the world today. Tune in to hear the highs, the lows, and everything in between of this industrial era disease, and feel free to leave your decompression schedule at home. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-08-30
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Ep 103 Leptospirosis: Don't blame the rats

The story of leptospirosis is chock full of variety. In terms of biology, any number of different Leptospira species and serovars can play a role in infection, and the resulting infection can run from asymptomatic to deadly. As for ecology, virtually any mammalian species can either act as an affected reservoir for the pathogens or fall victim to a deadly infection. The history of leptospirosis takes us across continents and through centuries, illustrating how changes in scientific thought and technology shaped our understanding of this and other zoonotic diseases. And the current status of this One Health disease is no less varied, both in the wide distribution of leptospirosis as well as the vastly differing (but disturbingly high) estimates of annual cases and deaths. In this episode, we do our best to tackle as much of the variety in this neglected disease as we can, from its impact on us and our furry friends, to the classic story of its discovery and the biggest remaining gaps in our knowledge today. Tune in for all this and more! Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-08-16
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Ep 102 Arsenic: Paris Green with Envy

?The king of poisons,? ?the poison of kings,? ?inheritance powder.? As its various nicknames suggest, arsenic?s notoriety largely stems from its use as a murder weapon. But as we explore in this episode, the world of arsenic is much, much bigger than just as a plot device in an Agatha Christie novel, and it remains one of the most important environmental contaminants today. But how exactly does arsenic affect your body? When did people first start to use arsenic and for what purposes? Where does it have the most impact currently? And, of course, why was it so popular as a murder weapon? Tune in to hear the answers to these and many, many more questions about one of the most notorious poisons out there. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-08-02
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Ep 101 Immortality: This Podcast Won't Kill You

For what was originally going to be our 100th regular season episode, we wanted to turn the vaguely threatening title of our podcast on its head by exploring a topic that?s not about something that can kill you but rather the hows and whys of staying alive, forever. That?s right, this week we?re taking on the immense and amorphous concept of immortality, viewed primarily through the lens of biology. Why don?t humans or any other organisms live forever, evolutionarily speaking? What can the long search for an elixir of life tell us about our future prospects of life without end? How close has current technology brought us to achieving immortality in even the remotest sense of the word? This may not be your typical TPWKY episode, but we promise laughter, trivia, and existential contemplation about the meaning of life, so you?re not gonna want to miss it. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-07-19
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Ep 100 Monkeypox: Here we go again?

A little over two years into a pandemic, the last thing you probably want to see is headlines announcing yet another disease spreading across the globe. And yet, here we are. Beginning in May 2022, an increasing number of cases of monkeypox have been reported in many countries around the world, both in places where the monkeypox virus is known to occur as well as places where it had previously never been observed. And although the monkeypox virus itself is not new, some of the ways it is acting during this outbreak are. In this episode, we take you through what we knew about monkeypox before this outbreak began, first by exploring the biology of this poxvirus and how it makes you sick before walking through the history of its discovery and past epidemics. Then we shift our focus to the ongoing outbreak: What is different about the patterns we?re seeing today compared to past outbreaks? How has the virus changed? How exactly is it transmitted? And, a question we haven?t asked in a very long time, how scared do we need to be? Tune in to hear us address these questions and many more about this re-emerging poxvirus. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-07-12
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Ep 99 Salmonella: A hard egg to crack

We?ve all been there: doubled over in pain as stomach cramps grip your guts; the panicked shuffle to the nearest bathroom; the waves of nausea and chills as you cry out loud, ?oh no, what did I eat???.  At the very least, food poisoning is a humbling experience, but at the worst, it can be absolutely deadly. In this episode, we take a deep dive into one group of pathogens commonly responsible for outbreaks of food-borne illness, the infamous Salmonella. We start first with an exploration into how and why these bacteria make you sick before turning towards the history of these pathogens, a history which includes a brief jaunt through a bizarre story involving a cult, bioterrorism, and a small Oregon town. Finally, we wrap up the episode with a look at Salmonella by the numbers today. You?ll leave this episode brimming with Salmonella knowledge, thinking twice about how well you cook your chicken or wash your veggies, and contemplating how fast you can get your hands on a food thermometer. Trust us - you?re not gonna want to miss this one! Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-06-21
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Ep 98 Folate: Marmite, anyone?

It?s been years since our first (and, until now, only) vitamin-centric episode on scurvy, and we?re thrilled to be dipping our toes back into these nutritious waters with this episode on folate. Have you ever wondered why folate is important or what the difference is between folate and folic acid? Or maybe you?re curious about this vitamin?s discovery and the impact that fortification programs have had around the world. Look no further - this episode has got all the folate facts you could desire. Tune in to hear how antifolates are used in cancer treatment, where folate got its name, and what a famous savory food spread has to do with the history of this essential vitamin. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-06-07
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Special Episode: Snake Venom Evolution

Our snake venom episode last week took us down some fascinating roads, from the pathophysiological effects of these compounds to the snake detection hypothesis and from the development of antivenom to the incidence of snakebite around the world today. But how did we make it through that whole episode without discussing how and why these venoms evolved in the first place? It?s because we were saving it for this one, where we enlisted the expert help of Professor Nick Casewell, Professor of Tropical Disease Biology at the Liverpool School of Tropical Medicine and Director of the Centre for Snakebite Research & Interventions. In this bonus episode, the last in our series for now, Professor Casewell takes us through the remarkable world of snake venom evolution, covering such topics as the genetic basis for venom evolution, how snake venom is related to prey type, why spitting cobras spit, and so much more. Tune in wherever you get your podcasts to gain an even greater appreciation for these venom-producing snakes as well as the brilliant people who research them! Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-05-31
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Ep 97 Snake Venom: Collateral Damage

How do you feel about snakes? Intrigued or terrified? In awe or creeped out? Of course, those aren?t the only options; the sight or thought of a snake can evoke many different emotions, but chances are indifference isn?t one of them. And is it any wonder? Some snakes can produce incredibly potent venoms that can seriously harm or even kill you, a characteristic that likely helped earn them their prominent role in many cultures and religions as a creature or god to be respected, if not feared. In this episode, we take a closer look at the diverse compounds that make up these venoms by exploring how they impact our bodies in the myriad ways they do and the current tools we have to combat their effects. Then we turn to evolution, not of snakes themselves but rather the role snakes may have played in primate evolution (snake detection hypothesis, anyone?) before discussing the historical development of antivenoms. We round out the episode by reviewing the current status of snakebite as a neglected tropical disease and mentioning some very exciting therapies on the horizon. Don?t missssss out on this enlightening envenoming episode today! Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-05-24
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Special Episode: Coprolites!

Our tapeworm episode last week mentioned the remarkable finding of tapeworm eggs in a 270 million-year old shark coprolite, that is, fossilized feces. And this certainly wasn?t the first time coprolites have come up on the podcast; we?ve referenced them several times before, mostly when discussing early histories of parasitic worms. But there is so much more to the world of coprolites than just which parasites were found and when. To help us explore all that coprolites can teach us is the world-renowned paleontologist Dr. Karen Chin, Professor at University of Colorado Boulder and Curator of Paleontology at CU-Boulder Museum of Natural History. In this exciting bonus episode, Dr. Chin takes us on a fascinating tour of the what (what are coprolites?), the why (why are they important?), the how (how do feces get preserved?), and the who (who dung it?) of these incredible trace fossils. Learn more about your ad choices. Visit megaphone.fm/adchoices
2022-05-17
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